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Public AI explainer video

Chronic Stress Dysregulation in the Human Brain

Why can stress stay active after the danger is gone? Think of a thermostat. It senses the room, compares it with a target, and turns heat on when cold...

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Chronic stress dysregulation in the human brain

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Why can stress stay active after the danger is gone? Think of a thermostat. It senses the room, compares it with a target, and turns heat on when cold or off when warm. Your stress response follows a similar loop: the brain-body system detects threat, activates heart, attention, and hormones including cortisol, then eases as safety returns. But repeated or prolonged stress can miscalibrate that thermostat. It may become too sensitive, or recovery may weaken, so the response returns easily or lasts too long. That's the flip: stress stops responding to danger and becomes poorly regulated threat-and-recovery loop. This is not simply a choice to calm down. Dysregulation can involve timing, sensitivity, recovery, or coordination across brain and body. Chronic stress does not mean cortisol stays high; responses vary by person and situation. Because the brain's thermostat can read safety as threat and fail to turn the response down.